The High Radiosensitizing Efficiency of a Trace of Gadolinium-Based Nanoparticles in Tumors
نویسندگان
چکیده
We recently developed the synthesis of ultrasmall gadolinium-based nanoparticles (GBN), (hydrodynamic diameter <5 nm) characterized by a safe behavior after intravenous injection (renal clearance, preferential accumulation in tumors). Owing to the presence of gadolinium ions, GBN can be used as contrast agents for magnetic resonance imaging (MRI) and as radiosensitizers. The attempt to determine the most opportune delay between the intravenous injection of GBN and the irradiation showed that a very low content of radiosensitizing nanoparticles in the tumor area is sufficient (0.1 μg/g of particles, i.e. 15 ppb of gadolinium) for an important increase of the therapeutic effect of irradiation. Such a promising and unexpected result is assigned to a suited distribution of GBN within the tumor, as revealed by the X-ray fluorescence (XRF) maps.
منابع مشابه
Efficacy of radiosensitizing doped titania nanoparticles under hypoxia and preparation of an embolic microparticle
The aim of this study was to develop a manufacturing protocol for large-scale production of doped titania radiosensitizing nanoparticles (NPs) to establish their activity under hypoxia and to produce a multimodal radiosensitizing embolic particle for cancer treatment. We have previously shown that radiosensitizing NPs can be synthesized from titania doped with rare earth elements, especially ga...
متن کاملThe effect of gold nanoparticles on dose enhancement factor of human intestinal colon cancer HT-29 cells
Introduction: Radiation therapy is an important procedure for treatment of more than half of tumors. One way to increase the efficiency of radiation therapy is application of radiosensitizer at the site of tumor. gold nanoparticles (GNPs) have several characteristics that make them attractive for using with radiation therapy including small size (1–100 nm), biocompatibility, pr...
متن کاملRelevance between MRI longitudinal relaxation rate and gadolinium concentration in Gd3+/GO/alginate nanocomposite
Objective(s): Relevance between magnetic resonance imaging (MRI) relaxation rate and concentration of magnetic nanoparticles determines the capability of a nanomaterial to provide MRI contrast. In the present study, alginate was conjugated to gadolinium/graphene oxide nanocomposite to form gadolinium/graphene oxide/alginate nanocomposite, aiming to investigate its effect on the relevance betwee...
متن کاملSize Reproducibility of Gadolinium Oxide Based Nanomagnetic Particles for Cellular Magnetic Resonance Imaging: Effects of Functionalization, Chemisorption and Reaction Conditions
We developed biofunctionalized nanoparticles with magnetic properties by immobalizing diethyle-neglycol (DEG) on Gd2O3, and PEGilation of small particulate gadolinium oxide (SPGO) with two me-thoxy-polyethyleneglycol-silane (mPEG-Silane 550 and 2000 Da) using a new supervised polyol route, described recently. In conjunction to the previous study to achieve a high quality synthesis and increase ...
متن کاملSize Reproducibility of Gadolinium Oxide Based Nanomagnetic Particles for Cellular Magnetic Resonance Imaging: Effects of Functionalization, Chemisorption and Reaction Conditions
We developed biofunctionalized nanoparticles with magnetic properties by immobalizing diethyle-neglycol (DEG) on Gd2O3, and PEGilation of small particulate gadolinium oxide (SPGO) with two me-thoxy-polyethyleneglycol-silane (mPEG-Silane 550 and 2000 Da) using a new supervised polyol route, described recently. In conjunction to the previous study to achieve a high quality synthesis and increase ...
متن کامل